Shenzhen New Value Capital Management Co.,Ltd.

Information Details

A Brief Introduction to SEEG

2023/08/24

What is SEEG

Determining the exact location of the seizures requires a diagnostic procedure called SEEG. Place 10-15 electrodes in the brain. Electrodes are implanted in areas of the brain where seizures are suspected. To insert each electrode, a small incision is made in the skin and a small hole is made in the bone, just enough for the electrode to pass through. Each electrode is held in place by a bolt attached to the bone. During the patient's hospitalization, the head is wrapped in bandages, so screws or electrodes are not visible. The surgery takes 1-2 hours, after which the patient is transferred to the epilepsy intensive care unit (EMU). THIS METHOD WAS FIRST INVENTED BY FRENCH DOCTORS TALAIRACH AND BANCAUD, AND HAS GRADUALLY BEEN INTRODUCED INTO CLINICAL PRACTICE BY DOMESTIC PROFESSIONAL HOSPITALS IN RECENT YEARS.

The implantation of the deep electrode is carried out under general anesthesia and can be roughly divided into five steps -

The first step: through stereotactic frame or robot guidance, the skull is drilled, with a diameter of about 2.1mm;

Step 2: Screw the guide screw on the skull to guide and fix the electrode implantation;

Step 3: Open the dura with electrocoagulation electrode to stop bleeding locally;

Step 4: Use the probe to open a channel to ensure that the trajectory on the electrode implantation will not be deflected;

In the fifth step, deep electrodes are implanted. After the electrode implantation is completed, EEG can be monitored in the ward, EEG results can be analyzed, and the three-dimensional brain network transmission form and precise epilepsy lesion localization can be constructed.

Market analysis

There are 5500 million epilepsy patients in the world and 1000 million epilepsy patients in China, with an incidence rate of 4.6-7‰ (of which, 40,10 new people and 2014,750 refractory epilepsy patients in China every year). It is understood that SEEG technology began to be implemented in China in 1500, and it is still in the stage of supply-side bottlenecks leading to demand-side demand that cannot be effectively released, and the total potential market size is <> billion yuan to <> billion yuan, which is still a huge blue ocean market.

It is expected that the market size of SEEG can reach 2024-30 billion / year (50-25,30 sticks) in <>.

Main players

1) Reushenan

Through years of development, Ruishenan Medical has accumulated strong strength, research and development capabilities, innovation capabilities and production capacity in the field of active implantable medical devices and neuromodulation.

The company focuses on epilepsy, pain, Parkinson's, depression, Alzheimer's disease and other important areas of brain science research, and is committed to providing comprehensive solutions for the treatment of diseases, not just a single product。 On October 2021, 10, the new generation of SEL-20XX series intracranial brain electrodes (SEEG) independently developed and produced by Ruishenan Medical was officially approved for marketing. The contacts of the intracranial brain electrode of Ruishenan are made of platinum-iridium alloy, which has excellent biocompatibility and high sensitivity; The electrode impedance is small, the signal conduction performance is superior, and the attenuation is small. At the same time, in clinical trials, RESIAN SEEG verified the safety of 4.3T nuclear magnetic examination, and all materials were non-magnetic (electrode contacts are platinum-iridium alloy, guide screws are titanium alloy, and guide wires are nickel-cobalt alloy).

2) Huake precision

Huake Precision (Beijing) Medical Technology Co., Ltd. is a company focusing on medical robot technology and intelligent medical product innovation, located in Beijing Zhongguancun High-end Medical Equipment Park. At present, the team has developed more than ten kinds of products including various medical robots, medical navigation, medical software, medical electrodes, medical lasers and so on. The company's team began the successful attempt of intelligent medical innovation in 2003, and gradually completed more than 90% of the domestic replacement of this field through the independent technological innovation and industrialization of intracranial electrodes, supporting more than 5000,<> related surgeries every year, which directly promoted the development of functional neurosurgery in China.

Huake's precision intracranial electrode is the first intracranial electrode for epilepsy lesions in China, covering 20+ regions and accounting for 90% of the market.

3) Knoll Medical

Nuoer Medical has been focusing on creating an epilepsy EEG AI-assisted decision-making system based on SEEG electrode, so on the product side, stereotactic electroencephalogram (SEEG) diagnosis and treatment products adopt a combination of software and hardware, and the software realizes automatic identification, annotation and judgment of brain wave abnormalities through core algorithms to achieve auxiliary diagnosis; In terms of hardware, electrode products (1st and 2nd generation) for refractory epilepsy diagnosis and laser ablation products (3rd generation) for epilepsy treatment are deployed to achieve the integration of diagnosis and treatment.

At present, Nuoer Medical has developed a generation of 3.0T magnetic resonance-compatible stereotactic EEG electrode and 1.0 AI-assisted intelligent detection system based on epilepsy waves.

4）佳量医疗

Founded in 2020, Hangzhou Jialiang Medical Technology Co., Ltd. is a high-tech enterprise focusing on the field of neurosurgery and brain science research. The company is committed to the research and development of internationally leading innovative treatment options for refractory epilepsy and other neurological diseases, aiming to become a trusted solution leader in the field of neuromedicine worldwide. It has the leading stereotaxic magnetic resonance compatible electrode in China.

The investment research team of Xinhenglida believes that surgical resection surgery is an important treatment for drug-refractory epilepsy, and SEEG technology, as the best solution for precise preoperative localization of epileptogenic foci, has been rapidly promoted and applied in Europe, America and China in recent years. At the same time, with the promotion of products and technologies such as extrajudicial surgical robots, functional iteration of key clinical instruments (such as SEEG electrode 3.0T magnetic resonance compatibility), SEEG EEG AI-assisted decision-making, etc., the efficacy rate of refractory epilepsy diagnosis will be improved from all links, and the number of domestic SEEG surgeries will expand rapidly in the future.

Next Drug King? Atopic Dermatitis (AD) Treatment Drug

Analysis of Three Architecture Requirements for Optical Modules